Feliciano Lopez and David Ferrer recorded singles wins on the first day to give the visitors a commanding 2-0 lead over USA in Austin.
On Saturday, the Bryans gave the crowds some hope by winning the doubles match but
David Ferrer played admirably on Sunday, securing a 3-1 lead over USA and putting Spain in the semifinals.
The full results are listed below:
R1: Feliciano López (ESP) d. Mardy Fish (USA) 4-6 6-3 3-6 7-6(2) 6-8
R2: David Ferrer (ESP) d. Andy Roddick (USA) 6-7(9) 5-7 3-6
R3: Bob Bryan / Mike Bryan (USA) d. Fernando Verdasco / Marcell Granollers (ESP) 6-4 6-4 6-4
R4: David Ferrer (ESP) d. Mardy Fish (USA) 5-7 6-7(3) 7-5 6-7(5)